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KMID : 0366219900250010289
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Korean Journal of Hematology
1990 Volume.25 No. 1 p.289 ~ p.293
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A Case of Microgranular Acute Promyelocytic Leukemia
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이위교/Wee Gyo Lee
김원배/이동화/강득용/홍대식/박회숙/Won Bae Kim/Dong Wha Lee/Duk Yong Kang/Dae Sik Hong/Hee Sook Park
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Abstract
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Microgranular acute promyelocytic leukemia(APL) is a morphologic variant of APL
and is known to be easily mistaken as acute monocytic leukemia.
The leukemic cells are characterized by bilobed or multilobed nuclei and bluish
agranular cytoplasms. The presence of small number of promyelocytes containing
multiple Auer rods(faggot cells) is necessary for the correct diagnosis.
Recently we experienced a case of microgranular APL in 14 years old girl who
presented with leukopenia including 70% of leukemic cells. The leukemic cells had
folded, bilobed nuclei and agranular to only finely granular cytoplasm and faggot cells
are occasionally found. The cytochemical studies revealed strong positive reactions on
peroxidase, homogenous weakly positive reactions on PAS and negative reactions on
alpha-naphthyl acetate esterase stain. The chromosomal study revealed 46,XX without
evidence of translocation. The electron photomicrographs of agranular promyelocytes
show small granules which range 200-300nm and dilated rough endoplasmic reticulum.
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